Tinidazole

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Trichomoniasis Cure Rates with TINDAMAX®

Trichomoniasis cure rates with Tindamax: 96% of females and 94% of males cured.

†Average of 4 studies1-4 with cure rate range of 92-100% at 1 week to 1 month post-dosing.

‡ Average of 4 studies5-8 with cure rate range of 83-100%.

Tinidazole (2 g single oral dose) use in trichomoniasis has been well documented in 34 published reports from the world literature involving over 2,800 patients treated with tinidazole.

In four published, blinded, randomized, comparative studies of the 2 g tinidazole single oral dose where efficacy was assessed by culture at time points post-treatment ranging from one week to one month, reported cure rates ranged from 92% to 100%.1-4

The single oral 2 g tinidazole dose was also assessed in four open-label trials in men (one comparative to metronidazole and 3 single-arm studies). Parasitological evaluation of the urine was performed both pre- and post-treatment and reported cure rates ranged from 83% to 100%.5-8

Tinidazole has a minimal therapeutic advantage over metronidazole for the treatment of trichomoniasis. In metronidazole-resistant trichomoniasis, tinidazole (in a variety of dosages) has achieved cure rates of 90% and higher.9,10

For trichomoniasis, the most important difference between the two drugs may be that tinidazole is more tolerable and less toxic than metronidazole, even at high doses.10,11

See Cure Comparison for more information.

  1. O-Prasertsawat P, Jetsawangsri T. Split-dose metronidazole or single-dose tinidazole for the treatment of vaginal trichomoniasis. Sex Transm Dis. 1992 Sep-Oct;19(5):295-7.
  2. Gabriel G, Robertson E, Thin RN. Single dose treatment of trichomoniasis. Int Med Res. 1982;10(2):129-30.
  3. Hillström L, Pettersson L, Pálsson E, Sandström SO. Comparison of ornidazole and tinidazole in single-dose treatment of trichomoniasis in women. Br J Vener Dis. 1977 Jun;53(3):193-4.
  4. Aimakhu V. Vaginal trichomoniasis: one stat dose of tinidazole compared with a seven day course of metronidazole. W Afr Med J. 1975 Apr;97-100.
  5. Beric B, Pribicevic V, Djordjevic M, Pavlovic N. Clinical studies on the therapeutic effect of tinidazole ("Fasigyn") during treatment of urogenital trichomonas infections in women and men (with comparative laboratory studies on the effect of metronidazole and tinidazole) Zentralbl Gynakol. 1978;100(24):1594-9.
  6. Massa M, Arias B, Subiabre V, Rojo M. Ensayo terapeutico de la infeccion por Trichomonas vaginalis en el hombre mediate una dosis unica de tinidazol. Bol Chile Parasitol. 1976 Jan-Jun;31(1-2):46-7.
  7. Wallin J, Forsgren A. Tinidazole--a new preparation for T. vaginalis infections. II. Clinical evaluation of treatment with a single oral dose. Br J Vener Dis. 1974 Apr;50(2):148-50.
  8. Fantini E, Leguen J, Kellemberger J, Rubi R. Treatment of trichomoniasis in males with a single dose of a new imidazole derivative. Sem Med. 1974 Jul;46-50.
  9. Mammen-Tobin A, Wilson JD. Management of metronidazole-resistant Trichomonas vaginalis--a new approach. Int J STD AIDS. 2005 Jul;16(7):488-90.
  10. Sobel JD, Nyirjesy P, Brown W. Tinidazole therapy for metronidazole-resistant vaginal trichomoniasis. Clin Infect Dis. 2001 Oct 15;33(8):1341-6. Epub 2001 Sep 17.
  11. Nailor MD, Sobel JD. Tinidazole for the treatment of vaginal infections. Expert Opin Investig Drugs. 2007 May;16(5):743-51.
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